Bob Koure
1 min readAug 20, 2022

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>>working through complex information became harder

AKA "brain fog"? If so, there's been some interesting work showing that methylene blue (yes, blue jeans ‘indigo’ dye) has a positive effect.

I ran into the work as I've been tracking Francisco Gonzales-Lima's work on Alzheimer's Disease. He posits its origin as mitochondrial dysfunction coming from down-regulation of cytochrome c oxidase, which impairs electron donation and so impairs electron chains 1 and 3; methylene blue works as a substitute electron donor.

Interestingly (to me, anyway) he's also shown positive results using near-IR light shone on the forehead - photons can work in place of electrons. He used 1005nm light to sidestep the absorption spectra of hemoglobin. The skull is relatively transparent to this light. But the only area affected is the frontal cortex (primarily decision making) so if that's not what's foggy, might not do anything.

Also, if you decide to try methylene blue, be sure to get the USP version; the industrial versions have (somewhat scary) toxic inclusions.

Do your own research (ie go to PubMed, search for F Gonzales-Lima or methylene blue), don't go on my word. If I had the issue, I think I'd start with 0.5mg per kg, maybe go up to 1. It's been shown safe up to 4mg per kg.

Hoping you're better by the time you read this.

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Bob Koure
Bob Koure

Written by Bob Koure

Retired software architect, statistical analyst, hotel mgr, bike racer, distance swimmer. Photographer. Amateur historian. Avid reader. Home cook. Never-FBer

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