As the old saw goes: "That's a heck of a nice pen you've got there — bet you write good stories with it!"
That said, ergonomics count for a lot. Being able to get the setting you want from a knob or button on the outside of the camera (no menu diving) makes it easier to capture the shot you have in mind.
I went from Nikon film to Nikon digital (same glass) and started digital with a used D7000. One afternoon, at an overlook, I was trying to help someone with a D5000. It handled just like my camera — but the button I was trying to show them to ‘just do’ what they wanted wasn’t on that camera.