This intestinal / microbiome damage is in addition to what fructose (table sugar, sucrose is half fructose) is doing to us. It signals our bodies to switch from primarily metabolizing glucose to storing it as fat. This is common in many animals, as it's a survival trait (store fat for the lean times ahead after gorging on fruit available in the fall) - but we humans have it more than most, likely because the climate changed in our history making food more seasonal - and the survivors were the ones able to build large fat stores. They had a 'uricase mutation' - which also means we have to get vitamin C from the diet (unlike, say, rodents). Nicely laid out here: https://onlinelibrary.wiley.com/doi/full/10.1111/joim.12993 I'd TL;DR it, but it's an easy read.