The diterpenes that come from coffee (cafestol, kahweol) are pretty interesting pharmacologically.

They're about the only thing that can lower Lp(a) - other cholesterol lowering drugs (statins, PCSK9 inhibitors) can lower all particles, but this is more targeted.

There are studies that show diterpenes (mostly cafestol) can raise serum triglycerides, but that most of this rise disappears if the diterpenes are taken over a long period of time.

There are also a lot of positive effects of diterpenes: anti-inflammation (what turns a fatty deposit on an artery into arteriosclerosis and NAFLD into steatosis), anti-carcinogenic, induces apoptosis, anti-angiogenic (keeps solid tumors from recruiting surrounding cells). Also, there are anti-diabetic properties (AMPK activator, seems to reduce cellular tendency to accumulate lipids — and we know that trigs in muscle cells become DAGs that interfere with glucose uptake). On top of that, it has anti-osteoclast properties (if that gets out of hand, there’s osteoporosis, also bone metastasis of cancer and arthritis — scary list). There are more positive things; this is just a highlights reel.

Sooo… maybe don’t worry so much about unfiltered coffee. :-)

Also — if you work for pharma, both cafestol and kahweol seem to be interesting places to start a drug investigation.