Thanks for bringing this up! I read his book (same title as the podcast) when it came out, hadn't realized he'd come out with a podcast.
For anyone interested in getting deeper into the science of how it all works, I'd highly recommend Dr Peter Attia's "Drive". Most episodes are free. If you subscribe, you get some more plus access to amazingly thorough show notes (each one is like being in graduate school). I was aware of Dr Sinclair because of an interview he had with Dr Attia on the Drive.