>>Saturated fats have been associated with greater incidences of heart and vascular disease.
Not accepted as fact anymore. Ancel Keys has done a lot of damage.
That said, there is at least one set of alleles that have been associated with serum high levels of fat leading to insulin resistance - more a matter of degree of susceptibility, if you look at some of the fMRI intracellular work that's come our over the last decade or so. As a retired person I can relate to not keeping up with recent work. I haven't picked up a copy of IEEE Spectrum in a few years. Enough already. :-)