Regarding hyper­lipidemia as an AD risk factor, it’s not clear that treating that with a statin, particularly an oleophilic statin, is a major improvement. Trade one kind of dementia for another?

I wonder if non-statin treatments for hyper­lipidemia (e.g. niacin, or a bile-binder) offers any protection.

I’m rather struck by the lack of good supporting evidence connecting lowering lipids with cardiac artery disease. Yes, there’s an effect with statins, but not with those other lipid lowering approaches, which leads me to think that statin protectivity is coming from some other factor, possibly inflamation reduction(?)