Bob Koure
2 min readMar 20, 2024

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>> Notably, at the 6-week mark, there were no discernible differences in health outcomes among the groups.

These are pre-diabetics. They're not actually diabetic until fasting glucose (FPG) goes up - and that seems to be more a glucagon issue (release of glucose from the liver) than one of glucose disposal. And HbA1c is a very slow-moving indicator.

That said, I've taken to avoiding saturated fats as I have a SNP that links a high dietary input to a greater risk of T2DM.

How did I figure that out?

- I got a readout on my own genome. I used 23andMe because it was the cheapest (then $99)

- I downloaded a text version of that genome.

- I sent the text file to promethase.com, got a 'report' that aligns my SNPs with published GWAS (genome wide association studies) to see if there was anything I needed to look out for (e.g. APOE4, BRCA1, etc.)

- I figured out how to read the report. If you're trying to do this as well, I highly recommend an article here at Medium: 3 filters to understand your Promethease report: a review for DNA newbies to get started. BTW/FWIW, there's at least one company that allows you to 'link' your account with Promethase. If you've ever uploaded or downloaded 'cloud' data to say, Google Drive, you probably don’t need this, but if it’s the cheapest way...

Another interesting place to look is your MTHFR status. You can get that at Promethase, but it’s more intelligible at Chris Masterjohn’s section on MTHFR. MTHFR is important for conversion of multiple B vitamins — and those in turn are critical for how our cells get energy (Krebs / citric acid cycle) as well as recycling homocysteine (high levels of which are bad).

Finally, if you find Promethase overwhelming, there’s a much easier to read analysis available at FoundMyFitness.com.

Hope that this helps someone…

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Bob Koure
Bob Koure

Written by Bob Koure

Retired software architect, statistical analyst, hotel mgr, bike racer, distance swimmer. Photographer. Amateur historian. Avid reader. Home cook. Never-FBer

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