I did a quick look at the links in your article. I'm not sure it's referenced, but after doing a search for TAGLN3 I came up with APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation.

To quote a snippet:

… We show that APOE4 exerts a dominant negative effect to prime astrocytes toward a pro-inflammatory state that is pharmacologically reversible by TAGLN3 supplementation. …

I’ve no idea how they reversed things with “TAGLN3 supplementation”. Adding the full article to my list of must-reads. (which is getting absurdly long… sigh)