Great summary!
Interesting that one of the triggers is anoxia. I can't help but wonder if this is somehow connected to the 'energy crisis' model of AD put forth by a number of researchers, notably Francisco Gonzalez-Lima who has done interesting work aleviating AD with both methyline blue and trans-cranial near-IR. Both MB and NIR serve as stand-in electron donors in ETC complex 1 in mitochondria and so somewhat alleviate the issue as chtochrome C (what's normally used) levels drop under energy stress (including anoxia). FWIW, methyline blue (at much higher dosages) is standard of care for carbon monoxide poisoning (another kind of anoxia).
Then there's Rick Johnson's work showing that anoxia can trigger the production of fructose which as it's metabolized via the uric acid system depresses the number of mitochondria.
As you mention, people suffering RLS have disturbed sleep, and there's a correlation between that and the risk of AD - so even if RLS and AD both fit the 'energy crisis' model, disturbed sleep will be a confounded.
All that said, for anyone with RLS *please* check in with your doctor before taking iron supplements. High levels of iron can do bad things (technical term).
Finally, there have been some interesting things going on with klotho and brain health - and some studies indicating that the amino acid ergothionine is mitogenic (back to the 'energy crisis'). Interestingly (to me, at least) levels of both go up with exercise. I find all this *fascinating* - but I'm kind of a nerd.