Given that astrocytes are the major source on CNS IL3, failing astrocytes present a "double whammy" as they're also needed to convert glucose into the glycogen used by neurons.

Those neurons can alternatively use ketone bodies.

Patients suffering from Alzheimer's show cognitive improvement when taking ketone salts - which suggests that their astrocytes, for whatever reason, are not converting glucose into glycogen at normal (non disease) rates.

Astrocytes also protect neurons from toxins - and the NRF2 pathway is important for that. See https://pubmed.ncbi.nlm.nih.gov/19490732/

One key to activating NRF2 is dietary isothiocyanates (e.g. sulforaphane from broccoli, moringin from the moringa 'tree').

Time to eat your broccoli!

BTW, sulforaphane comes from two substances that combine when the cells are crushed. One of these is destroyed by cooking - but you can replace it by eating cooked broccoli with mustard (IMO it's actually a pretty good combination). Another route is to sprout broccoli seeds.