>>[from the study] ...induced pluripotent stem cells exhibit multiple inter-related bioenergetic alterations including: changes in energy production by mitochondrial respiration versus glycolysis, as a consequence of alterations in bioenergetic substrate processing and transfer of reducing agents, reduced levels of NAD/NADH, diminished glucose uptake and response rates to insulin (INS)/IGF-1 signaling, ... <<

Sounding a bit like diabetes type 3...?

There's some indication that the type 2 cascade starts with some kind of mitochondrial disfunction in the skeletal muscles, leading to fat buildup around those mitochondria, then leading to insulin resistance (interference with the uptake tubule mechanism).

Disclaimer: non-bio guy here, got interested when my dad was diagnosed with type 2 30-ish years ago, have been looking at research ever since.