Bob Koure
1 min readMay 13, 2022

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>>Everyone claims to hate clickbait headlines, but research shows they tend to work.

Well, yes - but if I notice a series of click-bait titles from a particular author, I mute them. Might be worth mentioning that to the editors here?

That said, I think a lot of the confusion (and mixed research results) on TRE comes from how early/late in the day the eating window happens to be. If you look at the work Sachen Panda has done, you'll see that an early window (so the eating window lines up with the circadian clock) shows an effect, while a evening window pretty much does not.

I've been doing TRE on-purpose for about a year - and multiple decades before that by accident (not eating before I got into the water - best time slot was around 1PM). So not early. I'd like to try early, but I'm the cook in the family, and making dinner for everyone but me just doesn't work.

I expect I'm still getting the benefit of fuel partitioning flexibility even with late TRE. Most of those TRE studies look at blood glucose - but I haven't found any that also track insulin (normal glucose curve with elevated insulin is insulin resistance, indicating a partitioning issue. If you're interested in the etiology of IR, check Gerald Shulman's fMRI work (TL;DR: cellular diglycerides)

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Bob Koure
Bob Koure

Written by Bob Koure

Retired software architect, statistical analyst, hotel mgr, bike racer, distance swimmer. Photographer. Amateur historian. Avid reader. Home cook. Never-FBer

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