Bob Koure
Nov 3, 2023

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As we are mammals with the 'uricase mutation', that's another possible cause. In marine mammals high sodium is a trigger to produce fructose which so the body can produce 'metabolic water'. If you've wondered where whales get drinking water, it's via this mechanism. There's been some research of late showing that it works this way in humans, too. If it's this, then simply being dehydrated can trigger it, too as that also spikes sodium. Here’s a link to how it works in mice:
High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism

It’s IMO a fascinating area. If you’re a paid subscriber to Peter Attia’s podcast, there’s one ‘cast with Rick Johnson that goes into the molecular biology (not sure how much is available to everyone, but check).

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Bob Koure
Bob Koure

Written by Bob Koure

Retired software architect, statistical analyst, hotel mgr, bike racer, distance swimmer. Photographer. Amateur historian. Avid reader. Home cook. Never-FBer

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