>>All-in-all, the article gives an interesting perspective on how insulin resistance might have been a survival advantage.

I've been thinking about African Americans vs just-West-Africans (where the enslaved people were kidnapped from). The ones descended from the ones that survived the third passage seem to be both more salt sensitive (HBP) and more fructose-sensitive (obesity / diabetes) than the ones still in Africa. So I suspect having this uricase mutation in both alleles made a survival difference. If you missed it, the fructose trigger is also about storing metabolic water, meaning you can go longer without water with this activated.

Nothing official or published here, just something I've been thinking about since, well, since I was in college in the 70s.

As far as evolution. look at what's happened to native peoples when presented with the Western diet (particularly the Inuit).

My dad was a 'brittle' insulin dependent type 2. First detected around 55-60. Progressed though metformin to insulin - and never 'cheated' on his diet. I very much wish I'd known what I know now back when he was 50. Sigh. He made it to 86, not bad for someone with type 2.

But you can see why this is an area of interest for me, as well as both genetics and epigenetics (turns out both Mendel and Lysenko were right, respectively).

Cheers!